Clinical: Weird symptoms that no one can diagnose?

When your symptoms seem 'weird' to both you and your doctor always consider Lyme disease.

I had a man in his late 40's who I have seen once a year since 1990 for a physical. Apart from basket ball mishaps no other problems. All of a sudden he popped up complaining of an itchy rash along his belt line and we assumed he had developed a nickel allergy. I gave him a steroid cream and the rash went away but not the itching. His body had itching all over, off and on, with low grade hives. That weekend he was out to dinner with his wife and felt like he was going to pass out, was he dehydrated? It was, after all the height of summer. I ran an ECG on him and it was different from the ones he had been getting annually. Thank goodness he had been so consistent with his physicals.
The EGC was the final clue and I ran a Lyme disease test on him. It was the highest I have ever seen!
Within two days of starting treatment, he began to feel like his old self.

His new normal had consisted of fatigue and constant itching and 'weird symptoms' that changed from day to day.  Based on his blood test I would assume that he had had Lyme disease for quite awhile.
He had no recollection of a tick bite, joint pains or a target lesion on his skin which are the classic symptoms of Lyme infection. Sometimes its just a general feeling of not being well, or generalized body aches and malaise. It is always good to check.
In the meantime, prevention is better than cure. Check yourself and your pets for ticks when you come in from the outside especially if you have been in the yard or hiking. Insect repellants may also help.